If you don't know anything about HEY, you should check out the features tour. It is a great overview that highlights many of their unique features. https://hey.com/features/the-screener
HEY also shipped with a Linux client from day one, and that's what I've been using. There is a client for each platform. https://hey.com/apps
Email signatures? https://twitter.com/dhh/status/1276311062057369600
Custom domains for individuals? https://twitter.com/jasonfried/status/1273725369489727490
IMAP is probably the only qualm I have about it so far. I understand it doesn't make sense for the HEY client, but it'd be nice to manage my email from other clients. And that's not going to happen. https://twitter.com/dhh/status/1272599759686000640
Still, if there is a company I can trust with vendor lock-in, that's Basecamp. And I don't say this lightly. If worse comes to worse, their policies on what happens after cancelling the account are good. https://twitter.com/dhh/status/1275503946962857984
In summary, my experience has been really good so far. To be fair though, I was already doing fine with my previous setup. Even though this is a big improvement, I feel it's only noticeable for power users. I get ~5 emails a day, so email has never been overwhelming for me.
But something important for everyone, not only power users, is who your email provider is. I share a lot of values with Basecamp, and that comes through in the product. I didn't with Google, and that's why I ended up using 3rd party clients.